Some are game changers, but many are yielding incremental advances at best.
of dollars on cancer care each year, a portion of which is paid out of pocket by patients themselves.The 92 new cancer drugs approved for the first time between 2000 and 2016 extended overall survival by a median of only 2.
But overall, even as the total number of drug approvals spiked each year, the portion of those drugs that were truly novel declined, according to the JAMA study. Since blockbuster drugs are known to work on a particular target, companies "keep tweaking that pathway and coming up with variations on a theme, and that does come at the exclusion of other potentially novel targets," says Russell Pachynski, a professor of oncology at Washington University in St. Louis who specializes in prostate cancer.
"If it is effective, [CAR-T] is a one dose therapy — once and done," says Yvonne Chen, a scientist at UCLA who designs CAR-T cells. Factoring in the total cost of medical care, "it is far more economically efficient compared to having three, four, five lines of therapies that eventually fail or fail from that start."The pipeline of cancer drugs in development is enormous. Although many of them are variations on — and new combinations of — existing treatments, others could deliver the next big advances.to try to target solid tumor cancers and reduce side effects.
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