A study published in the Journal of Neuroinflammation finds that lymph node enlargement is closely related to macrophage activation and contributes to the peripheral inflammation in Parkinson’s disease.
]. Whether the harmful species like aggregated α-syn in the CNS were involved in the peripheral inflammation in PD or related disorders through meningeal lymphatic drainage is largely unknown.
All experiments were carried out on male mice at 8-month age. For A53T mice, age-matched B6C3F1/J mice were selected as the control group. Mice in the same experimental group were randomly selected from different cages. For TUDCA treatment, 7-month-old A53T mice were intraperitoneally injected with TUDCA at a dose of 100 mg/kg/day for 1 month.
For brain collection, after lymph node collection, the mice were decapitated above the shoulders. Then, the top of the skull was removed with surgical curved scissors by cutting clockwise, and the brain was collected for further study.
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