The association between omega-3 polyunsaturated fatty acid intake and reduced risk of Alzheimer's disease AJCNutrition omega3 fattyacids alzheimers alzheimersresearch dementia health news
By Pooja Toshniwal PahariaApr 7 2023Reviewed by Lily Ramsey, LLM In a recent study published in The American Journal of Clinical Nutrition, researchers evaluated the association between omega-3 polyunsaturated fatty acids intake, cognitive decay, and dementia.
However, observational-type studies reported unclear findings concerning omega-3 supplement efficacy in preventing AD, cognitive decay, and dementia. Further, the team performed a systematic review and meta-analysis of previously published cohort-type studies to verify the associations between dietary omega-3 fatty acid intake and biomarkers and cognitive decay or dementia.
Blood samples were obtained from all participants. The team quantified the composition of fatty acids using Nightingale Health's nuclear magnetic resonance metabolomics and serological metabolites using NMR spectroscopy. Results Among ADNI study participants, 46% were female, and the mean duration of follow-up was 2.8 years. Individuals developing AD showed apolipoprotein E-carrying tendency. Long-term omega-3 consumers showed a 64.0% reduction in AD risk .
Initially, 18,230 records were identified after reviewing the titles and abstracts, of which 709 records were considered, and after detailed evaluation, 48 studies were eligible for the analysis, 31 of which were considered for the meta-analysis, comprising 103,651 individuals.
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