In 2001, Gleevec was approved as a treatment for chronic myelogenous leukemia. It was a revelation for personalized medicine—with harrowing financial repercussions that persist today.
That's the short version anyway. A closer look at what followed after the FDA approval, on the other hand, paints a different picture., after conveying the enthusiasm, concluded by pointing out that the drug sold for well over $2,000 a month. That translated into an annual cost of between $25,000 and $30,000. The Novartis CEO admitted the price was steep, but there was good reason, he countered. The existing therapies for chronic myelogenous leukemia were priced similarly.
Around 2006, the price began climbing. The market for Gleevec had indeed expanded after its release because it changed a deadly blood cancer into something that could be managed like a chronic disease, which by the Novartis CEO’s own reasoning should have brought the price down. Around the same time several other drugs that worked similarly, called “tyrosine kinase inhibitors” based on the proteins that they shut down, also came out alongside Gleevec. One, in fact, was Novartis’ own Tasigna.
The chronic myelogenous leukemia community, appalled by what was unfolding, eventually cried foul. In 2012, patients and loved ones of those with the diseaseasking members of Congress to intervene on Novartis’ price hikes. One patient who was in Druker’s original trial of STI-571 complained, “It is borderline criminal to force people to make the choice between life and death .” Another supporter of the petition simply pleaded, “My grandma needs this medicine.
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