Researchers find connections in the brain involved in epileptic seizures uclnews
After 3 years, disconnection of anterior thalamic and striatal projections was associated with seizure freedom. Pie charts show patients being seizure free or seizure-relapsing according to each tract being disconnected or preserved. Each tract group includes the same tract in the left and right hemisphere. Also, after 5 years, disconnection of anterior thalamic and striatal projections was associated with seizure freedom.
To rule out whether worse long-term seizure outcome was caused by partial resection, we performed a second analysis to test the influence of cortico-thalamostriatal disconnection on long-term seizure outcome in those 29 patients for whom total resection of the lesion was achieved . At the 3-year follow-up, only one of the 12 patients in whom the anterior thalamocortical projection was resected had seizure recurrence compared to 11/17 patients for whom this was preserved [χ< 0.002].
We next ran a similar tractography analysis using normative data. This also showed disconnection of the anterior thalamic radiation was significantly associated with seizure outcome after 3 years [85% versus 64% streamlines resected in seizure-free/seizure-recurrence groups;
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