New research offers more evidence linking targeted therapies for patients with advanced renal cell carcinoma to higher risks for major adverse cardiovascular events.
The two groups had similar gender, age and socioeconomic levels. Combined, the groups were 74% male, the median age was 63, and 68% hadAfter stabilized inverse probability of treatment weighting, the adjusted incidence rates of major cardiovascular events were 6.65 and 3.36 per 100 person-years in the targeted and cytokine therapy groups, respectively."The higher cardiovascular risk of the targeted group was driven primarily by the VEGFR TKI–treated patients," the authors wrote.
Two drugs were linked to statistically significant higher rates of major cardiovascular adverse events compared with the reference drug=.021) and the mTOR temsirolimus . Sunitinib was by far the most commonly used targeted therapy drug. Among patients on targeted therapy, several factors were linked to higher rates of major cardiovascular events, such as baseline history of
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