Study reveals subtle brain asymmetry differences in schizophrenia Brain Neurology MedTwitter Schizophrenia Neuroscience PNASNews
By Tarun Sai LomteApr 3 2023Reviewed by Benedette Cuffari, M.Sc. A recent study published in the Proceedings of the National Academy of Sciences analyzes structural brain asymmetries in schizophrenia.
Altered asymmetry of the cortex in schizophrenia has been reported in studies with small cohort sizes. The enhancing neuroimaging genetics through meta-analysis consortium, which conducts large-scale analyses, previously reported cortical thinning, altered subcortical volume, and smaller surface area in schizophrenic individuals relative to controls. However, these prior ENIGMA studies did not evaluate asymmetry.
Volumes for eight bilaterally paired regions from a neuroanatomic atlas of subcortical structures were derived. The right and left hemispheric measurements were used to estimate the asymmetry index . Findings Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The whole-hemisphere average cortical thickness and surface area asymmetries were not significantly different between cases and controls. However, a small but significant difference in the thickness asymmetry of the middle temporal gyrus and rostral anterior cingulate cortex was observed between cases and controls at the regional level.
The thickness asymmetry of the rostral anterior cingulate cortex was not different between medication groups. In contrast, a nominal but significant increase in the mean rightward asymmetry was observed in cases taking first-generation antipsychotics for the middle temporal gyrus; however, these differences were not significant upon multiple testing corrections.
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