Study provides understanding of SARS-CoV-2 pulmonary infection long-term effects at the microanatomical, cellular, and molecular level medrxivpreprint WeillCornell SARSCoV2 COVID19 coronavirus covid infection pulmonary
By Pooja Toshniwal PahariaDec 5 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers evaluated compositional and structural pulmonary alterations in PASC [post-acute coronavirus disease 2019 ] tissues.
Multiplexed imaging analysis was performed to analyze the pulmonary tissues of 12 individuals who died post-acute coronavirus disease 2019 and to compare them to those of individuals who died during the acute COVID-19 phase or individuals who died with UPI/IPF , and otherwise healthy lung tissues . A 39-antibody panel capturing multiple structural and immunological pulmonary compartments was designed, and the antibody clones were validated by immunofluorescence analysis and chromogenic staining.
The team investigated the severe acute respiratory syndrome coronavirus 2 presence in AT-2 cells, validated by in situ hybridization, polymerase chain reaction , and immunohistochemistry. Pulmonary neutrophil deployments of extracellular traps were quantified, and pathology-specific and time-specific processes were deconvoluted, contrasting time-associated tissue alterations since acute COVID-19 across all individuals and PC subgroup differences.
Contrastingly, interstitial and peri-bronchial macrophages were significantly greater among all diseases compared to healthy lungs. More dense fibroblasts and vascular endothelial cells in the walls of the airways and the cluster of differentiation 4+ T lymphocyte cells were observed among PC tissues compared to healthy lungs and acute SARS-CoV-2 infection tissues. In PC-neg samples, a greater density of alveolar type-2 cells was observed.
In PC tissues, vascular endothelial cells in airway walls were denser. More widespread ectopic microvasculature with significantly more numerous smooth muscle cells in alveolar septa and peri-bronchial areas was observed. The extracellular citrullinated H3 NET marker expression was significantly greater among PC cells than in healthy lung tissues.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2 biorxivpreprint WUSTLmed SARSCoV2 COVID19 coronavirus covid infection
Weiterlesen »
Impact of COVID-19 booster vaccination and breakthrough infectionResearchers assessed the protection elicited after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) booster vaccination or a breakthrough infection against SARS-CoV-2 Omicron variant infection.
Weiterlesen »
Infectious Covid virus can stay on some groceries for daysScientists did the study for the government to better understand possible exposure to shoppers.
Weiterlesen »
Half of Scots cutting back spending, study findsCitizens Advice Scotland says soaring energy costs are forcing people to rein in household spending.
Weiterlesen »
Nasa's thermal mole reveals active mantle plume on MarsDiscovery shows 'astrobiological potential of subsurface habitable environments,' researchers say
Weiterlesen »
America’s syringe exchanges might be killing drug usersNow that HIV is no longer a death sentence and opioids are more fatal than ever, the costs of drug addiction are far higher than they were—and the benefits of reduced HIV infections are lower
Weiterlesen »