Study investigates vitamin C's effectiveness in treating gout and hyperuricemia Gout VitaminC Hmong microbiome Obesity Urine COVID Saliva Gut bacteria PLOSONE UMNews
They have published the protocol of this phase II clinical study in the journal PLOS ONE.
In the United States, the prevalence of gout is almost 4%, with certain ethnicities exhibiting even higher prevalence. The Hmong community residing in Minnesota has a 2-fold higher prevalence of gout and a 5-fold higher prevalence of uric acid renal stones compared to the non-Hmong population. The study also aims to explore the interplay between vitamin C supplementation, taxonomic and functional patterns of gut microbiota, and serum urate-lowering effect of vitamin C. Moreover, the study will explore the relationship between obesity, gut microbiota, and gout. The study will screen for differential microbial biomarkers and selected genetic variations impacting the urate-lowering ability of vitamin C in Hmong adults with or without gout.
Study intervention The participants were asked to orally consume 500 mg of vitamin C twice daily for 8 weeks. To increase treatment adherence, participants were asked to maintain a record of their vitamin C intake. Follow-up reminders were also sent to them at weeks 1, 4, and 7.
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