Study investigates the interplay between acute stress and placebo effects in nausea SciReports unisouthampton LMU_Muenchen uconnhealth nausea sickness stress placebo
By Pooja Toshniwal PahariaJun 21 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Scientific Reports, researchers investigated the interplay between acute stress and placebo effects on nausea.
Likewise, placebo effects depend on social, psychological, and biological interactions. Nausea is often experienced during stress, such as surgery or chemotherapy. Studies have reported clinically meaningful effects of placebo treatment on nausea; however, the impact of stress on these effects is not well characterized, warranting further research.
The treatment group participants received a positive verbal suggestion of nausea improvement, followed by transcutaneous electrical nerve stimulation therapy for 20 minutes. In the placebo intervention, the TENS electrodes were attached distoproximal to dummy acupuncture points on the ulnar forearm region, followed by superficial TENS massage for 20.0 minutes. The team induced nausea with a virtual optokinetic drum and repeatedly assessed humoral, behavioral, and psychophysiological parameters.
Among stressed individuals, the placebo therapy benefits on motion sickness and nausea persisted, whereas the NTT ratios did not improve. After the placebo treatment, nausea severity was significantly lowered, confirming that positive expectations were induced following placebo therapy. Stress neither affected nausea expectations nor interacted with treatment.
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