Depression is not correlated with low serotonin levels, finds an umbrella study that fundamentally challenges long-held scientific understandings of depression and antidepressant medications.
The research, which evaluated 17 meta-analyses and reviews, was the first to synthesize and comprehensively examine studies on serotonin levels, receptors, related genes, and precursor molecules. Its researchers found no evidence for low serotonin-related depression.
The study authors are hopeful that discrediting the serotonin-depression hypothesis, believed by 80% of the general public, will change conversations about emotions and. Without the assumption that depression is entirely chemical, they argue, people with depression may feel more optimistic about their ability to self-regulate and manage their symptoms.
In debunking the influential serotonin-depression theory, the new research has sparked new questions about our scientific understandings of depression. Thirteen percent of American adults take SSRIs, a class of antidepressants that were thought to fight depression by increasing serotonin levels
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