Researchers have unveiled the hidden intricacies of how sperm go from passive bystanders to dynamic swimmers. This transformation is a pivotal step in the journey to fertilization, and it hinges on the activation of a unique ion transporter.
Researchers at Stockholm University have unveiled the hidden intricacies of how sperm go from passive bystanders to dynamic swimmers. This transformation is a pivotal step in the journey to fertilization, and it hinges on the activation of a unique ion transporter.
"SLC9C1 operates like a highly sophisticated exchange system. It swaps protons from inside the cell for sodium ions from the outside, temporarily creating a less acidic environment within the sperm. This change in the internal environment triggers increased sperm motility," says David Drew, Professor in Biochemistry at Stockholm University.
"The VSD domain responds to the change in voltage by pushing its rodlike S4 helix inwards. This clears the way for ion exchange by SLC9C1, ultimately initiating sperm motility," says David Drew.
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Sperm's secret voltage switch: Scientists unlock the mystery of motilityResearchers at Stockholm University have unveiled the hidden intricacies of how sperm go from passive bystanders to dynamic swimmers. This transformation is a pivotal step in the journey to fertilization, and it hinges on the activation of a unique ion transporter. Their research has been published in Nature.
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