Christopher J. Harrison, MD, wonders about the pros and cons of vaccinating children aged 6 months to 5 years old against COVID-19.
The AAP and ACIP recommend the mRNA vaccines.
And like other pediatric vaccines, it should be no surprise that boosters will be needed, even if no newer variants than Omicron BA.4/BA.5 arise. But we know newer variants will arise and, similar to influenza vaccine, new formulations, perhaps with multiple SARS-CoV-2 strain antigens, will be needed every year or so. Everyone will get SARS-CoV-2 multiple times in their lives no matter how careful they are.
Another major issue has been “safety concerns” about the vaccines’ small amount of mRNA for the spike protein encased in microscopic lipid bubbles injected in the arm or leg. This mRNA is picked up by human cells, and in the cytoplasm produces a limited supply of spike protein that is then picked up by antigen-presenting cells for short-lived distribution to regional lymph nodes where immune-memory processes are jump-started.
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