Two big names have signed up for the dark comedy.
Fyodor struggles with a gambling addiction, and this "continues to cause problems for the couple until they are forced to return to a Russia that is not quite as they remember".
On joining the cast, Wood said she was "overjoyed" to be working with the "singular Malgo" on the project. She continued: "Her work hits me right in the heart and gut. She has such a wonderful ability to combine searingly truthful humanity with dream-like magic. "Within reading the first few pages of the brilliant script, I felt beyond excited to play Anna and bring to life her mix of stoicism, eccentricity, mischief and wisdom. And I can’t think of anyone better to play Dostoevsky than Matt. I’m thrilled!"Dillon echoed her sentiments, saying he is "really excited to be a part of this project and to be working with Malgo to bring this incredible character to life".
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Sex differences in the polygenic architecture of hearing problems in adults - Genome MedicineBackground Hearing problems (HP) in adults are common and are associated with several comorbid conditions. Its prevalence increases with age, reflecting the cumulative effect of environmental factors and genetic predisposition. Although several risk loci have been already identified, HP biology and epidemiology are still insufficiently investigated by large-scale genetic studies. Methods Leveraging the UK Biobank, the Nurses’ Health Studies (I and II), the Health Professionals Follow-up Study, and the Million Veteran Program, we conducted a comprehensive genome-wide investigation of HP in 748,668 adult participants (discovery N = 501,825; replication N = 226,043; cross-ancestry replication N = 20,800). We leveraged the GWAS findings to characterize HP polygenic architecture, exploring sex differences, polygenic risk across ancestries, tissue-specific transcriptomic regulation, cause-effect relationships with genetically correlated traits, and gene interactions with HP environmental risk factors. Results We identified 54 risk loci and demonstrated that HP polygenic risk is shared across ancestry groups. Our transcriptomic regulation analysis highlighted the potential role of the central nervous system in HP pathogenesis. The sex-stratified analyses showed several additional associations related to peripheral hormonally regulated tissues reflecting a potential role of estrogen in hearing function. This evidence was supported by the multivariate interaction analysis that showed how genes involved in brain development interact with sex, noise pollution, and tobacco smoking in relation to their HP associations. Additionally, the genetically informed causal inference analysis showed that HP is linked to many physical and mental health outcomes. Conclusions The results provide many novel insights into the biology and epidemiology of HP in adults. Our sex-specific analyses and transcriptomic associations highlighted molecular pathways that may be targeted for drug developme
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