Severe hepatitis outbreak linked to common childhood viruses ucsf nature
is rare, and doctors were alarmed when they started seeing outbreaks of severe unexplained hepatitis. There have been about 1,000 cases to date; 50 of these children needed liver transplants and at least 22 have died.2 . AAVs are not known to cause hepatitis on their own. They need"helper" viruses, such as adenoviruses that cause colds and flus, to replicate in the liver.
Once they returned to school, children were more susceptible to infections with these common pathogens. The study suggests that for a small subset of these children, getting more than one infection at the same time may have made them more vulnerable to severe hepatitis. "We were surprised by the fact that the infections we detected in these children were caused not by an unusual, emerging, but by common childhood viral pathogens," said Charles Chiu, MD, Ph.D., professor of laboratory medicine and medicine in the Division of Infectious Diseases, director of the UCSF Clinical Microbiology Laboratory, and senior author of the paper.
"That's what led us to speculate that the timing of the outbreak was probably related to the really unusual situations we were going through with COVID-19 related school and daycare closures and social restrictions," Chiu said."It may have been an unintended consequence of what we have experienced during the last two-to-three years of the pandemic."
By August 2022, clusters of cases were reported in 35 countries, including the U. S., where 358 cases were under investigation. The Centers for Disease Control and Prevention launched an investigation into the causes.
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