Biologists uncover mechanism that shapes centromere distribution. Since the 1800s, scientists have noted the configuration of centromeres, a special chromosomal region that is vital for cell division, in the cell nucleus. However, up until now, the determining mechanisms and the biological signific
The upper panel shows non-Rabl configuration. Centromeres in magenta dispersed in nuclei in green. The lower panel shows Rabl configuration. Centromeres unevenly distributed in nuclei. Credit: Sachihiro Matsunaga, The University of TokyoSince the 1800s, scientists have noted the configuration of centromeres, a special chromosomal region that is vital for cell division, in the cell nucleus.
“The biological function and molecular mechanism of the Rabl or non-Rabl configuration has been a mystery across the centuries,” said corresponding author Sachihiro Matsunaga, professor at the University of Tokyo’s Graduate School of Frontier Sciences. “We successfully revealed the molecular mechanism to construct the non-Rabl configuration.”
“The centromere distribution for non-Rabl configuration is regulated independently by the CII– LINC complex and a nuclear lamina protein known as CROWDED NUCLEI ,” Matsunaga said. and in its Rabl-structure mutant. Because a change in the spatial arrangement of centromeres also changes the spatial arrangement of genes, the researchers expected to find differences in gene expression, but this hypothesis proved to be incorrect.
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