Is this the true cause of Alzheimer's disease?
"Yet the plaques remain the center of our attention as it relates to biomarker development and therapeutic strategies," Espay said in a university news release.
The team's previous research had found that regardless of plaque buildup in the brain, people with high levels of soluble amyloid-beta kept their brain health. On the other hand, those with low levels of the protein were more likely to have cognitive impairment. The researchers think soluble amyloid-beta levels decrease because the normal protein, exposed to stressors, starts transforming into abnormal amyloid plaques.
For this study, Espay and his team focused on amyloid-beta levels in a specific group of patients who carry mutations that predict they'd have more amyloid plaques in their brains -- and therefore should be more likely to develop
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