Researchers from the Technion and the University of Tokyo have identified unique peptides with potential anti-cancer properties. A study recently published in Nature Communications highlights the potential of unique peptides as anti-cancer agents. Peptides, which are short chains of amino acids con
The researchers believe that the new approach could be more effective than existing cancer drugs.
Unlike proteins that usually contain hundreds of amino acids, peptides contain – at most – dozens of such acids. The cyclic peptides the researchers discovered bind specifically to chains of ubiquitin proteins – proteins that are usually used as a “death tag” for damaged proteins. The labeling of the damaged proteins leads to their being broken down in the proteasome, or the cell’s “garbage can.”
The research was conducted by Professor Ashraf Brik, Dr. Ganga B. Vamisetti, and Dr.
Based on this approach, the researchers in a previous work developed cyclic peptides that bind the K48-linked ubiquitin chains, preventing them from leading to the breakdown of the damaged proteins. This disruption gradually leads to the programmed death of cells. In the same study, they hypothesized and then proved that when such an event formed in a malignant tumor, it kills the cancer cells, potentially protecting the patient.
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