Scientists uncovered over 3,800 tiny proteins that play a role in metabolism and discovered that one microprotein, Gm8773, boosts feeding activity in mice - offering a potential solution to help people with diseases like cancer gain weight. In the US, obesity and diabetes are widespread diseases.
Microproteins and small proteins called smORFs are potentially a rich source of uncharacterized regulators of metabolism. Credit: Salk Institute and Cell Metabolism
have found that both white and brown fat contain numerous unknown microproteins and one of these microproteins, Gm8773, has the ability to increase appetite in mice., could result in a therapeutic to increase weight in specific diseases such as during cancer chemotherapy. The team’s discovery of these microproteins also provides valuable resources for the scientific community to further study microproteins.
Fat tissue secretes many different proteins to regulate feeding, energy balance, and the production of heat. White fat, known as “bad fat,” is often found just beneath the skin and in the abdominal region. This type of fat acts as an energy storage depot and is related to obesity and other diseases caused by excess weight. In contrast, brown fat or “good fat” is located around the shoulders and along the spinal cord. Brown fat is associated with proper nutrition, exercise, and health.
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