The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study.
The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a study in mice from the National Eye Institute and the University of Freiberg, Germany. Without this external, stabilizing protein network, the AMPA receptors are no longer retained at the synapse, leading to weak, short-lived synaptic signals.
In a new study, a team of researchers led by Tomarev and Bernd Fakler, M.D., University of Freiberg, used biochemical and genetic methods to explore the complex network of extracellular proteins maintaining the localization of AMPA-type glutamate receptors at neural synapses. To better understand how the Noelins help regulate neuronal activity, the researchers developed mice lacking all three Noelin proteins. Without Noelins present, synapses in the mouse hippocampus had many fewer AMPA glutamate receptors. And when the researchers attempted to stimulate neurons lacking Noelins, the neuronal signals were much lower than normal.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Diseases and Conditions News -- ScienceDailyRead the latest research on diseases and conditions, symptoms, new treatment options and more. Updated daily.
Weiterlesen »
Patient Education and Counseling News -- ScienceDailyRead about current research on quality of life issues for patients, patient education and counseling.
Weiterlesen »
Dolphins and Whales News -- ScienceDailyWhales and dolphins. Whale songs, beaching, endangered status -- current research news on all cetaceans.
Weiterlesen »
Materials Science News -- ScienceDailyMaterials Science News and Research. Read all the latest in materials engineering, chemical engineering, and more.
Weiterlesen »
Insects (including Butterflies) News -- ScienceDailyCurrent event articles on insects and butterflies. Read about insect bites, butterfly migration, caterpillar growth, which insects are beneficial and how to deal with pests.
Weiterlesen »
Quantum Computers News -- ScienceDailyQuantum Computer Research. Read the latest news in developing quantum computers.
Weiterlesen »