Scientists thought they understood how our brains kept tabs on the levels of fat in our bodies: by monitoring fat-associated hormones in our bloodstreams.
While researchers have long known mammalian fat is riddled with neurons, these nerves were linked in animal models to the mammalian
"When we first started this project, there weren't existing tools to answer these questions," Scripps Research Institute neuroscientist Yu WangSo Wang and colleagues developed the tools, including a new imaging technique called HYBRiD and a targeted cell manipulation method called ROOT to overcome the technical difficulties of reaching neurons deep within our bodies' fat without messing them up. to allow close examination of large intact samples of tissue.
Losing the sensory neuron signal led to more fat in mice, with particularly high levels of brown fat. The mice also had higher body temperatures, which makes sense because brown fat helps our bodies convert other fats and sugar into heat.
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