wildDISCO uses standard antibodies to map the body of mice using fluorescent markers.
that allows researchers to explore their reference datasets and to make these data available to the scientific community in online atlases. The website contains high-resolution images of whole mouse systems like the nervous system, lymphatic system, and vascular system., “Knowing where each protein is expressed in the body is essential for developing a comprehensive understanding of how the body works and what goes wrong in complex diseases”.
Through this website, an online tool has been envisaged which will prove invaluable for biomedical research, allowing scientists to examine these systems in whole mice without the need to replicate the same experiments in the future, said the scientists in their study.First authors Dr. Hongcheng Mai and Dr. Jie Luo say, "Our online atlases have already generated data for published papers.
Scientists plan on integrating this method with artificial intelligence to understand diseases better. “Now imagine what we can do with these maps when you combine them with the power of deep learning,” said Ertürk. The team wants to harness the power of machine learning to simulate complex biological systems, in order to develop new treatments.Whole-body imaging techniques play a vital role in exploring the interplay of physiological systems in maintaining health and driving disease.
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