Scientists Accidentally Made a Mouse Grow Legs in Place of Genitals

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Scientists Accidentally Made a Mouse Grow Legs in Place of Genitals
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The team compared 10 to 17-day-old mouse embryos with and without functioning versions of the gene in question,Tgfbr1 contributes to a signaling pathway that gives a forming body its trunk-to-tail directions. This pathway provides a 'create a hindlimb' here, or 'external genitals' instructions to the developing embryo's cells.As a mammalian embryo grows, it builds structures sequentially from head to tail.

It's during this process that interactions between newly emerging tissues generate structures necessary for the body's exit channels and genitalia. "It will be therefore interesting to determine whether a mechanism related to the developmental plasticity uncovered by our work… could help the absence of hindlimbs in snakes but their presence in most lizards," Lozovska and colleaguesThe scientists found that despite the rather dramatically different placement of the extra legs in the embryos without a functioning version ofBoth appendages arise from the middle of three tissue layers that compose an early embryo, the.

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