SARS-CoV-2 Omicron BA.4.6 resistant to many therapeutic monoclonal antibodies in clinical use Antibodies Omicron SARSCoV2 Coronavirus Disease COVID biorxivpreprint ColumbiaPS q_nationaltaiwa
Study: Resistance of SARS-CoV-2 Omicron Subvariant BA.4.6 to Antibody Neutralization. Image Credit: Naeblys / Shutterstock
About the study The present study compared the spike protein binding affinity of the Omicron sub-variants BA.4.6, BA.4.7, and BA.5.9 against that of the globally dominant BA.5 sub-variant. The assays included the spike proteins from the lineages carrying R346T, R346S, and N658S point mutations and the spike proteins of the BA.4 and B.4 sub-lineages.
Results Related StoriesThe study results showed that Omicron sub-variants BA.4.6, BA.4.7, and BA.5.9 exhibited similar binding affinities to the dimeric human angiotensin-converting enzyme 2 receptor compared to the BA.5 subvariant. The pseudoviruses carrying point mutations also displayed binding affinities similar to BA.4.6.
Additionally, the therapeutic monoclonal antibody combination of cilgavimab and tixagevimab was found to be ineffective against all three newly emergent mutated sub-variants.
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