GreenLight Biosciences Holdings disclosed in a state notice that it would lay off 96 workers from its site in Lexington, Massachusetts -- that's about 37% of its workforce.
Shortly after agreeing to go private via a merger — and less than a year after its last round of layoffs — a Medford-based RNA firm is letting go of 96 employees.
GreenLight Biosciences Holdings disclosed in a state notice that it would lay off 96 workers from its site in Lexington. That's about 37% of its workforce, given that the company had 262 full-time employees in mid-March, based on its most recent annual filing.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Prominent epigenetic and transcriptomic changes in CD4+ and CD8+ T cells during and after pregnancy in women with multiple sclerosis and controls - Journal of NeuroinflammationBackground Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester of pregnancy. CD4+ and CD8+ T cells are implicated in MS pathogenesis as being key regulators of inflammation and brain lesion formation. Although Tcells are prime candidates for the pregnancy-associated improvement of MS, the precise mechanisms are yet unclear, and in particular, a deep characterization of the epigenetic and transcriptomic events that occur in peripheral T cells during pregnancy in MS is lacking. Methods Women with MS and healthy controls were longitudinally sampled before, during (1st, 2nd and 3rd trimesters) and after pregnancy. DNA methylation array and RNA sequencing were performed on paired CD4+ and CD8+ T cells samples. Differential analysis and network-based approaches were used to analyze the global dynamics of epigenetic and transcriptomic changes. Results Both DNA methylation and RNA sequencing revealed a prominent regulation, mostly peaking in the 3rd trimester and reversing post-partum, thus mirroring the clinical course with improvement followed by a worsening in disease activity. This rebound pattern was found to represent a general adaptation of the maternal immune system, with only minor differences between MS and controls. By using a network-based approach, we highlighted several genes at the core of this pregnancy-induced regulation, which were found to be enriched for genes and pathways previously reported to be involved in MS. Moreover, these pathways were enriched for in vitro stimulated genes and pregnancy hormones targets. Conclusion This study represents, to our knowledge, the first in-depth investigation of the methylation and expression changes in peripheral CD4+ and CD8+ T cells during pregnancy in MS. Our findings indicate that pregnancy induces profound changes in peripheral T cells, in both MS and health
Weiterlesen »
People on State Pension can quickly check eligibility for £3,500 top-up onlineIn just a few minutes you could find out if you are due an income boost from the passport benefit.
Weiterlesen »
Boost New State Pension pay without spending any money on missing NI yearsThe deadline to boost State Pension with voluntary NI credits has been extended until 2025.
Weiterlesen »
New delay for WASPI women waiting on review into State Pension age changesMillions of women born in the 1950s were affected by the change to the State Pension age.
Weiterlesen »
New calls to scrap State Pension income tax to stop 'penalising' retireesNew calls for income tax on State Pension to be scrapped to stop 'penalising' people in retirement
Weiterlesen »
State accused of ‘deliberately delaying’ information over GAA official's murder“The Brown family ask one simple question of the security forces: If you have nothing to hide why has it taken you 26 years to prove it? Hand over the documentation and let this inquest proceed.”
Weiterlesen »