Korean population study shows increased Parkinson'sdisease in rheumatoidarthritis patients jamaneuro
Findings
In this cohort study of 54 680 patients with RA and 273 400 individuals without RA, those with RA had a 1.74-fold higher risk of PD than those without RA. Patients with seropositive RA had a higher risk of PD than those with seronegative RA.The study’s findings suggest that physicians should be aware of the elevated risk of PD in patients with RA and that prompt referral to a neurologist should be considered at onset of early motor symptoms of PD without synovitis.
This retrospective cohort study used the Korean National Health Insurance Service database to collect population-based, nationally representative data on patients with RA enrolled from 2010 to 2017 and followed up until 2019 . A total of 119 788 patients who were first diagnosed with RA were identified during the study period and included those who underwent a national health checkup within 2 years before the RA diagnosis date . After applying exclusion criteria , 54 680 patients were included.
codes M05 for SPRA and M06 for SNRA; prescription of any disease-modifying antirheumatic drug; and enrollment in the Korean Rare and Intractable Diseases program.The main outcome was newly diagnosed PD. Data were analyzed from May 10 through August 1, 2022, using Cox proportional hazards regression analyses.From the 328 080 individuals analyzed , 1093 developed PD . Participants with RA had a 1.74-fold higher risk of PD vs controls .
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