Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization

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Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization
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Exposure to fungi can help sterile laboratory mice better model specific features of the human immune system, finds new research in SciImmunology.

We thank the NYU Grossman School of Medicine Flow Cytometry and Cell Sorting, Microscopy, Genomic Technology, and Histology Cores and M. Alva, J. Carrasquillo, and D. Basnight of the Gnotobiotics facility for their technical support and use of instruments.This research was supported by NIH grants DK093668 , AI121244 , HL123340 , AI130945 , AI140754 , DK124336 , and DK122698 , AI140754 , and Intramural Research Program of the NIAID, NIH .

L., K.Z., J.-D.L., and G.C.W.B.; generation ofstrains: S.-H.L. and R.J.B. Y.-H.C. and K.C. wrote the manuscript with the help of all other authors.K.C. has received research support from Pfizer, Takeda, Pacific Biosciences, Genentech, and Abbvie. K.C. has consulted for or received an honoraria from Puretech Health, Genentech, and Abbvie. K.C. is an inventor on U.S. patent 10,722,600 and provisional patent 62/935,035 and 63/157,225. V.J.T.

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