Science, Space and Technology News 2023
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Scientists at Tufts University School of Medicine have developed a genome-scale metabolic model or “subway map” of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully identified two compounds that selectively target routes only used by Lyme disease to infect a host.
“The Lyme bacterium is a great test case for narrow-spectrum drugs because it is so limited in what it can do and so highly dependent upon its environment. This leaves it vulnerable in ways other bacteria are not,” says Linden Hu, the Paul and Elaine Chervinsky Professor of Immunology, a professor of molecular biology and microbiology, and senior author on the study.
Gwynne and Hu are conducting other research to determine whether people with chronic Lyme symptoms are still infected or are suffering from an immune malfunction that creates chronic symptoms. “I can imagine a day when people take a targeted Lyme treatment for two weeks rather than a broad-spectrum antibiotic, are tested and determined to be clear of the infection, and then take drugs to tame their immune response if chronic symptoms persist,” says Gwynne.
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