A research team is exploring the correlations between the molecular structure, function, and dynamics of enzymes. Earlier this year, a significant discovery was made in the field of evolutionary conservation of molecular dynamics in enzymes. This advancement was led by Professor Nicolas Doucet and
Conformational changes experienced by proteins play an important role in their biological function and in enzyme catalysis. Professor Nicolas Doucet’s team is trying to elucidate how these dynamic events affect their molecular function, in addition to deciphering their evolutionary conservation among several homologous proteins and enzymes. These studies will help refine the development of new specific inhibitors in a therapeutic context.
Professor Doucet, a scholar with a focus on protein dynamics, is fascinated by the unseen yet profoundly mysterious elements vital to all life forms. He dedicates his research to the study of proteins and enzymes, striving to unravel the poorly grasped connections between their structure, function, and atomic-scale movement.
“A bit of imagination may be all it takes to envision multiple paths of inquiry in this tiny world we still know relatively little about, but the scientific process is very meticulous,” said Professor Doucet, a researcher at the Armand-Frappier Santé Biotechnologie Research Centre and scientific co-head of the Nuclear Magnetic Resonance Spectroscopy Lab at INRS.
“We studied different enzymes of the same family to analyze several proteins exhibiting the same biological function. We compared their atomic-scale motions to uncover whether they are preserved throughout evolution. Despite overall similarities between, we were surprised to find that, on the contrary, movements are divergent,” explained the lead author of the study, David Bernard, an INRS graduate who was a Ph.D. student in Professor Doucet’s lab at the time.
In the article, Professor Doucet’s team and their U.S. collaborators present a molecular and dynamic analysis of several ribonucleases, enzymes known as RNases that catalyze the degradation ofinto smaller elements. RNases from a handful of vertebrate species, including primates and humans, were selected based on their structural and functional homology.
For example, successfully inhibiting an enzyme by binding a drug to its active site while also targeting an allosteric site on the surface of a protein could kill two birds with one stone. The idea here is to inhibit the active site of the enzyme while at the same time disrupting its molecular dynamics by targeting an allosteric site. This inhibitory action would also significantly reduce the development of antibiotic resistance.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
50 years ago, enzyme injections showed promise for treating a rare diseaseToday, several rare diseases are treated via enzyme replacement therapy, and scientists have even found a way to treat one disease before a person is even born.
Weiterlesen »
The Exorcist Reboot Must Address 10 Mysteries & Questions About ReganWith a reboot of the Exorcist series confirmed for this year, there are many questions and mysteries surrounding Regan the reboot must address.
Weiterlesen »
Frisky Housewife Lets Revealing Robe Slip After Opening Door To Amazon Delivery DroneSEATTLE—Biting her lower lip while giving the hovering delivery aircraft a a sultry glance, frisky housewife Mia Jeffries reportedly let her revealing robe slip Friday after opening the door to her Amazon delivery drone. “Well, hello there big boy, I knew Amazon had a new fleet of prime drones, but I had no idea…
Weiterlesen »
New poll revealing Trump beating Biden could undermine the president’s caseNo matter how beleaguered President Biden has become, Democrats have held true to the belief that he could defeat former President Trump. A recent poll suggests otherwise.
Weiterlesen »
Actress Marcia Gay Harden attacks LGBTQ laws revealing, all of her children are 'queer'Actress Marcia Gay Harden revealed that all of her children were members of the LGBTQ community at a 'Drag Isn't Dangerous' telethon defending drag shows on Sunday.
Weiterlesen »