Bronchodilator therapy was no better than placebo at reducing respiratory symptoms in smokers. ERSCongress
accompanying the study in, Don D.
Her group hypothesized that ever-smokers with spirometric values that fall within the normal range — that is, a postbronchodilator FEV/FVC ratio of 70 or greater — would still derive benefit from long-acting bronchodilator therapy, even though these patients are currently excluded from Global Initiative for Chronic Obstructive Lung Disease recommendations.
A total of 535 participants were randomized, but COVID-19 pandemic–imposed obstacles resulted in a modified intention-to-treat population of 277 patients assigned to receive the active treatment and 244 assigned to receive placebo. There were four serious adverse events in the bronchodilator group and 11 in the placebo group, but none of the events were deemed to be related to the assigned treatments.
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