Mayo Clinic Comprehensive Cancer Center researchers have identified key findings that can assist clinicians in predicting whether a patient with advanced colorectal cancer will benefit from immunotherapy. The study was published in the journal Clinical Cancer Research and highlights the potential of using spatial analysis of specific proteins as a predictive tool for selecting appropriate candidates for PD-1 blockade immunotherapy in colorectal cancer, ultimately improving treatment outcomes and minimizing unnecessary treatments.
Mayo Clinic Comprehensive Cancer Center researchers have identified key findings that can assist clinicians in predicting whether a patient with advanced colorectal cancer will benefit from immunotherapy.
The study authors found that the distance between cells that express programmed cell death protein 1 and programmed cell death ligand 1 within the tumor can predict the outcome of immunotherapy inwith a defective DNA repair system, known as mismatch repair. PD-1 and PD-L1 are immune checkpoint proteins, primarily located on the surface of immune cells, whose binding is blocked by drugs known as checkpoint inhibitors.
"The finding suggests that this spatial analysis within tumors may be useful to select patients who are more likely to benefit from immunotherapy," says Frank Sinicrope, M.D., medical oncologist and gastroenterologist at Mayo Clinic Comprehensive Cancer Center."If cells expressing these proteins were at or within 10 microns of each other within the tumor, then immunotherapy treatment was able to significantly improve patient survival.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Researchers gain new insights into chromosome shortening and identify new potential cancer drug targetsA new study has provided insights into an important biological mechanism that supports survival of aggressive, hard-to-treat cancers, and in the process, has uncovered fascinating new information about how cells divide and grow.
Weiterlesen »
Study finds association between high dietary phosphorus and breast cancerResearchers evaluated associations of breast cancer incidence with different dietary phosphate levels.
Weiterlesen »
New surgical method for ovarian cancer lights up lesionsMayo Clinic scientists are shining light on ovarian cancer. A study published in 2022 in the Journal of Clinical Oncology explored the use of fluorescence-guided surgery to treat epithelial ovarian cancer, the most common type of ovarian cancer.
Weiterlesen »
Dental clinic boss died in Highlands mountain fallDr Nathan Turner, who owned a practice in Worcestershire, was killed in a hillwalking accident.
Weiterlesen »
Researchers develop new model to find potential treatment for neuromuscular diseasesResearchers from the Centre for Gene Therapy & Regenerative Medicine at King's College London, in collaboration with colleagues from University College London, have developed the first truly scalable human iPSC-neuromuscular disease model.
Weiterlesen »
INTEGRA Biosciences' vacuum aspiration systems help researchers solve the dog epigenomeResearchers in the Cho Lab at Seoul National University’s College of Veterinary Medicine, are using the VACUSAFE safe aspiration system and VACUSIP portable aspiration system from INTEGRA Biosciences to help them culture organoids from cancer-stricken domesticated dogs as part of a comparative medicine research initiative.
Weiterlesen »