Researchers identify glycolipid that blocks infection with SARS-CoV-2 and RSV NatureComms ColumbiaMed WUSTLmed infection SARSCoV2 COVID19 coronavirus virus
By Shanet Susan AlexJul 11 2023Reviewed by Benedette Cuffari, M.Sc. In a recent article published in Nature Communications, researchers discuss 7DW8-5, a glycolipid that utilizes the body's non-specific immune response to quickly combat viral infections, including the coronavirus disease 2019 in vivo.
Nevertheless, vaccine-breakthrough infections rose in frequency due to the continued spread of SARS-CoV-2 and evolution of viral variants. Thus, the development of novel preventive measures could reduce the transmission of SARS-CoV-2, such as those that utilize the host's innate immune system and facilitate quick infection control.
The efficiency of the glycolipid in blocking viral infections was tested in hamsters and mice infected with the SARS-CoV-2 Delta variant, as well as the Omicron BA.5 and BA.1 subvariants, in addition to the influenza virus and RSV. The Omicron subvariants were evaluated in wild-type mice, while the Delta variant was analyzed in keratin 18-human angiotensin-converting enzyme 2 transgenic mice.
Related StoriesThe mechanism of action of 7DW8-5 involves binding to CD1d on antigen-presenting cells and inducing NKT cells to release a series of chemokines and cytokines. The upregulation of genes were implicated in the non-specific immune response, particularly IFN-stimulated genes, was linked to the 7DW8-5-mediated protection against SARS-CoV-2 infection.
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