Stanford researchers find a new 'dump site' for misfolded proteins inside the cell.
Researchers at Stanford University's School of Humanities and Sciences have found a novel pathway that is used by the cell to dispose of misfolded proteins. Using advanced microscopy and live cell imaging techniques, the researchers were able to visually follow misfolded proteins and learn about their fate in the cell.. Previous research has shown that cells deal with misfolded proteins by either refolding them or simply eliminating them.
While the cytoplasmic inclusion can enter the vacuole easily, the nuclear envelope prevents the nuclear inclusion from doing the same. A few additional experiments later, the researchers concluded that the nuclear inclusion secreted special proteins that resulted in the bending of the nuclear envelope to facilitate the entry of the protein inclusion.
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