Commercially available mass spectrometers can be reliably used to detect the SARS-CoV-2 coronavirus, according to research from the Martin Luther University Halle-Wittenberg (MLU). In a study recently published in Clinical Proteomics, the researchers introduce a novel method that leverages equipment
Researchers have developed a method using commercially available mass spectrometers to detect SARS-CoV-2 in just two hours. The technique, utilizing MALDI-TOF spectrometry, is rapid and adaptable for detecting other pathogens, though it’s not as sensitive as the PCR test.coronavirus, according to research from the Martin Luther University Halle-Wittenberg .
The new method requires a nasal or throat swab. The sample needs to be prepared before it can be analyzed by a mass spectrometer, which takes only a few seconds. In MALDI-TOF mass spectrometry, a laser pulse is used to transfer the sample to the gas phase – then the mass of the individual components is measured.particles of the coronavirus.
“In acute phases, the method would make an ideal addition to PCR because we would be able to analyze a lot of samples very quickly. Rapid and reliable results may make it easier to contain outbreaks,” explains Lydia Kollhoff, lead author of the study. Moreover, the approach could be adapted rather easily to other pathogens in future pandemics and supplement PCR testing.
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