Scientists have created a method to detect key fat-filled particles known as lipoproteins in the central nervous system, opening a new view into the workings of the brain.
Researchers found that the particles in our nervous system, molecular cousins of the well-known HDL, or"good cholesterol" particles in our bloodstream, are much more diverse than previously thought. Researchers detected more than 300 different proteins associated with the particles, far more than the 16 known previously, that fall into at least 10 different families.
"What the heck is APOE4 doing? That's the big question. Why does one form translate to less risk for dementia while a slightly different form confers significant risk? Our technology brings us one step toward more answers," he added.circulatory system wrapped together travel in the bloodstream and carry out all sorts of important functions, like shuttling cholesterol and nutrients., APOE reigns supreme, serving as a scaffold to hold lipids and other proteins together. It also transports these nutrient-rich lipids and collections of molecular collaborators—groupings of proteins on its surface—throughout the nervous system to perform their tasks.
Scientists suspect APOE4 of playing a role in other neurologic conditions such as Parkinson's and Huntington's diseases, multiple sclerosis, amyotrophic lateral sclerosis and even traumatic brain injury.
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