Catching an earlier version of SARS-CoV-2 — particularly Omicron — provides some immunity against the two fast-spreading lineages.
People queue at a COVID-19 test site in New York City last month, when the BA.4 and BA.5 subvariants were taking hold.The Omicron BA.4 and BA.5 subvariants of SARS-CoV-2 have proven to be stealthier at evading people’s immune defences than all of their predecessors.
Everyone has a different immune history, because people have received different combinations of COVID-19 vaccines and been infected with assorted variants during the course of the pandemic. “Different histories equip people with different immunity against upcoming infection,” says Abu-Raddad. Knowing how these diverse immune responses interact inside a person will be “very important for the future of the pandemic”, he adds.
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