Future vaccine development may be inspired by the findings. Therapeutic antibodies that were effective early in the pandemic have lost their efficacy as SARS-CoV-2 has changed and mutated, and more recent variants, particularly Omicron, have learned how to circumvent the antibodies our systems prod
Future vaccine development may be inspired by the findings.SARS-CoV-2
“We hope that this humanized antibody will prove to be as effective at neutralizing SARS-CoV-2 in patients as it has proven to be thus far in preclinical evaluations,” says Frederick Alt, Ph.D., of the Program in Cellular and Molecular Medicine at Boston Children’s Hospital, who co-led the research., Alt and Sai Luo, Ph.D., utilized a modified version of a humanized mouse model that his lab had previously used to look for broadly neutralizing antibodies to HIV, another virus that often mutates.
Many of the existing antibodies work by attaching to the receptor-binding domain of the spike in certain regions, preventing SARS-CoV-2 from binding to our cells’ ACE2 receptors, which is the initial step in infection. The SP1-77 antibody binds to the RBD as well, but in a completely different manner that does not prevent the virus from binding to ACE2 receptors.
These features may inform the design of new SARS-CoV-2 vaccines. “SP1-77 binds the spike protein at a site that so far has not been mutated in any SARS-CoV-2 variant, broadly neutralizing current variants by a novel mechanism,” says Kirchhausen.
Österreich Neuesten Nachrichten, Österreich Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Democrats, environmentalists warm to nuclear power for quicker transition to a green energy futureOnce shunned by many Democrats and environmentalists, nuclear power is gaining acceptance among the party and activists as a clean alternative to fossil fuels, amid soaring energy costs and a sluggish transition to renewables.
Weiterlesen »
Comic Store In Your Future: Hot 25 Comics by Rodman ComicsHot comics are still heavy in demand. New comic movies mean new interest in comic characters that they are based on. The comic back-issue market is
Weiterlesen »
Apple seeks 'crumple-free' OLED panels for future iPad modelsApple would prefer to use a hybrid OLED panel for the iPad since it has less of a tendency to crumple as flexible OLED panels do.
Weiterlesen »
Plug-in hybrids can drive us to our fully electric futurePlug-ins make sense for consumers and automakers alike
Weiterlesen »