People hospitalized with COVID-19 may have higher heartfailure risk, study says NatureComms
. These discrepancies in reported inflammation may be related to the study populations or severity of COVID-19 infection. In an analysis of hospitalized patients with COVID-19 in the Mount Sinai Health System, cardiac injury was evident in 36% and was significantly associated with mortality. On the other hand, we did not observe differences in mean troponin levels at the index hospitalization, when comparing patients with vs. without COVID-19 infection.
There are some limitations in this study. First, clinical variables were extracted from the EHR and harmonized across four common data models, but are reflective of real-world practice and may be subject to residual heterogeneity. Second, the median post-discharge follow up time was approximately 1 year, and we were unable to consider longer-term sequelae. Third, we were unable to consider cardiac imaging and the majority of HF descriptions were nonspecific, e.g., “congestive heart failure”.
In conclusion, COVID-19 infection appears to be associated with an increased risk of incident HF. A suspicion of HF should be triggered in patients who experience respiratory or cardiac symptoms following recovery from COVID-19 hospitalization.The National COVID Cohort Collaborative represents a partnership between the Clinical and Translational Science Awards Program hubs , the National Center for Advancing Translational Science , the Center for Data to Health , and the community.
We conducted a secondary analysis of the “Level 2” deidentified N3C dataset, which redacted 17 personal identifiers and date-shifted longitudinal data to protect patient privacy. COVID-19 cases were included in our analysis if the first diagnosis date for COVID-19 occurred during inpatient hospitalization, inclusive of preadmission testing.
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Long-term neuromuscular consequences of SARS-Cov-2 and their similarities with myalgic encephalomyelitis/chronic fatigue syndrome: results of the retrospective CoLGEM study - Journal of Translational MedicineBackground Patients with long-COVID often complain of continuous fatigue, myalgia, sleep problems, cognitive dysfunction, and post-exertional malaise. No data are available on EMG recording of evoked myopotentials (M-waves) or exercise-induced alterations in long-COVID patients, providing evidence of muscle membrane fatigue. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) develops in more than half of patients after an infectious disease, particularly viral diseases. A large proportion (around 70%) of these patients have neuromuscular disorders with M-wave alterations during and after exercise. Our hypothesis was that M-wave alterations would be also found in long-COVID patients, in association with neuromuscular symptoms, similar to ME/CFS. Methods This retrospective observational ColGEM (Covid LonG Encéphalomyelite Myalgique) study compared 59 patients with long-COVID and 55 ME/CFS patients with a history of severe infection who presented before the COVID pandemic. All of these patients underwent the same protocol consisting of a questionnaire focusing on neural and neuromuscular disorders and M-wave recording in the rectus femoris muscle before, during, and 10 min after a progressive cycling exercise. Maximal handgrip strength (MHGS) and maximal exercise power were also measured. The frequency of symptoms and magnitude of M-wave changes in the two groups were compared using non-parametric and parametric tests. Results The frequency of fatigue, myalgia, sleep problems, cognitive dysfunction, and post-exertional malaise as well as the magnitude of exercise-induced M-wave alterations were the same in the two groups. By contrast, digestive problems were less present in long-COVID. M-wave alterations were greater in ME/CFS patients as in those with long-COVID when the highest muscle strength and highest exercise performance were measured. Conclusions These high clinical and biological similarities between long-COVID and ME/CFS support the hypothesis that S
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Barbados drops all Covid entry rulesThe lifting of Covid entry requirements are expected to boost tourism to the popular Caribbean holiday destination during the winter season
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Remdesivir resistance in transplant recipients with persistent COVID-19The medical community currently lacks robust data regarding the incidence, prevalence, and clinical significance of mutations associated with resistance to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) therapeutics. This report describes two renal transplant recipient...
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Resistance of Russian Rhinolophus bats containing ACE2-dependent sarbecoviruses to COVID-19 vaccinesIn a new study, researchers investigated the receptor tropism and serological cross-reactivity for spike (S) protein receptor-binding domains from two clade 3 sarbecoviruses found in Russian Rhinolophus (horseshoe) bats.
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This England star Ophelia Lovibond talks playing Carrie JohnsonThe Covid-19 drama following Boris Johnson's time as PM airs this week.
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