Blood-based biomarkers for Alzheimer'sdisease could greatly simplify diagnosis and reduce costs
This step would be a prerequisite to derive cohort-independent thresholds which would be necessary for a widespread clinical implementation. It is to be expected that different thresholds will be needed for different goals. Indeed, cut-offs might largely vary depending on the purpose , on the strategy adopted , and on individual characteristics of the included sample, for example, with different recommendations for different age ranges.
Furthermore, our sample mostly included patients with MCI, as it commonly happens in memory clinic populations,preventing us from drawing conclusions on the individual disease stages. For this reason, we chose not to focus on the individual disease stages, but to consider all patients as a unique memory clinic sample. The over-representation of MCI patients allows us to generalise our results to a wider memory clinic population undergoing biomarker testing .
Moreover, in the present study, we did not include the mass spectrometry version of plasma biomarkers. Finally, it is important to underline that the procedures described here include some specificities that might impact their performance. Factors that might lead to an overestimation of the diagnostic accuracy are the fact that the assessment of all experimental samples was performed in the same reference laboratory and based on only one or two analytical batches.
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