Researchers say this is a step toward animal-human transplants.
Surgeons transplanted a pig's kidney into a brain-dead man and for over a month it's worked normally — a critical step toward an operation the New York team hopes to eventually try in living patients.
"Is this organ really going to work like a human organ? So far it's looking like it is," Dr. Robert Montgomery, director of NYU Langone's transplant institute, told The Associated Press. Last year with special permission from regulators, University of Maryland surgeons transplanted a gene-edited pig heart into a dying man who was out of other options. He survived only two months before the organ failed for reasons that aren't fully understood but that offer lessons for future attempts.
Kidneys don't just make urine — they provide a wide range of jobs in the body. In the journal JAMA Surgery, UAB transplant surgeon Dr. Jayme Locke reported lab tests documenting the gene-modified pig organs' performance. She said the weeklong experiment demonstrates they can"provide life-sustaining kidney function.
The surgery itself isn't that different from thousands he's performed"but somewhere in the back of your mind is the enormity of what you're doing ... recognizing that this could have a huge impact on the future of transplantation," Montgomery said. One other trick: Surgeons attached the pig's thymus to the transplanted kidney in hopes that the gland, which helps train immune cells, would increase human tolerance of the organ. Otherwise, the team is relying on standard immune-suppressing drugs used by today's transplant patients.
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