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When darkness falls, sleep calls – except for the millions of shift workers who grind through the night. While the rest of us sleep, their health suffers.are common among shift workers who are fighting against their body clock to stay awake when they should be sleeping; not to mention eating at times when their metabolism is normally winding down.
The researchers disrupted the normal bodily rhythms of rats by giving the animals infusions of a hormone called corticosterone either in sync with or out of phase with light-dark cues.is to humans: a glucocorticoid hormone that rises steeply in the hours before waking and then drops off steadily throughout the day.
Although this altered timing wasn't associated with any weight gain or increase in fat mass, it was a huge departure from their usual feeding patterns – which the researchers traced back to greater activity at inappropriate times in genes that regulate appetite. "When we disturb the normal relationship of corticosterone with the day-to-night light cycle, it results in abnormal gene regulation and appetite during the period of time that the animals normally sleep," University of Bristol neuroscientist and study author Stafford Lightman
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