‘Personalized’ Cancer Vaccines Head to Phase III Trial

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‘Personalized’ Cancer Vaccines Head to Phase III Trial
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In an early trial, personalized cancer vaccines reduced the risk of recurrence or death among people with late-stage melanoma by 44%.

April 17, 2023 – Researchers this past weekend unveiled clinical trial results for a “major breakthrough” that would personalize cancer treatment.

The treatment approach uses mRNA vaccine technology that became well-known for its use in COVID-19 vaccines. The personalized cancer shots are created using information from an individual person’s tumor. The vaccines for people involved in the melanoma study were customized in 34 ways that were specific to a person’s tumor.

Among people in the vaccine group, 78.6% were alive and had not had a cancer recurrence 18 months later. In the Keytruda-only group, 62.2% were alive and had not had a recurrence. The metric is called “recurrence-free survival” among cancer researchers.

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