Patients with persistent depressive or cognitive symptoms after mild to moderate COVID-19 may have gliosis and inflammation, data suggest.
The investigators sought to determine whether levels of TSPO VT, which are quantifiable with PET, are elevated in the dorsal putamen, ventral striatum, prefrontal cortex, anterior cingulate cortex, and hippocampus of patients with COVID-DC, compared with patients without this syndrome. These brain regions were chosen, according to the authors,"because injury in these regions, which can cause gliosis, also induces symptoms of COVID-DC.
For patients with COVID-DC, motor speed on the finger-tapping test was negatively associated with dorsal putamen TSPO VT . The 10 participants with COVID-DC whose speed was lowest had higher mean dorsal putamen TSPO VT levels than control persons by 2.3 mL/cmThe investigators could not assess a possible association between the ventral striatum TSPO VT and anhedonia because all participants had these symptoms.
Research is ongoing."We are acquiring more information regarding different types of inflammation in the brain, whether there is ongoing injury, and whether treatments that influence inflammation are helpful," said Meyer.
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