Patients with cancer, suppressed immune system at high risk for severe COVID if treated with systemic drug therapies danafarber JAMAOnc
"We found that patients who were both immunocompromised and treated with immunotherapies did much worse than those who didn't receive these therapies," said Chris Labaki, MD, Dana-Farber, co-lead author on the paper. The other co-lead authors are Ziad Bakouny, MD, MSc, Brigham and Women's Hospital, and Punita Grover, MD, University of Cincinnati Cancer Center.
"Both cytokine storm and death from COVID were three to four times higher in this group," said Bakouny. The same trend held true, but to a lesser extent, for patients who were immunocompromised and received some types of systemic treatments."In this group cytokine storm and death from COVID were two to three times higher than in non-treated patients."
The findings hold important messages for patients with cancer as well as their physicians, the study authors said."Patients at high risk for severe COVID should take steps to keep that risk as low as possible: wearing a mask, avoiding crowded places, staying current with vaccines and boosters," researchers said.
"When we counsel patients about treatment, it's important that we discuss the benefits and risks of treatment with systemic therapies with respect to COVID-19," said Choueiri, who is also on the CCC19 steering committee. Dana-Farber is a founding CCC19 institution."The results of this study can help us know what to expect.
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