A personalised mRNA vaccine for pancreatic cancer has produced promising results in a small trial – here’s what you should know about the science and its implications
Was the vaccine the only treatment given in the trial?
No. The participants were also given chemotherapy, as is standard after surgery, says Macdonald. In this trial, they also received a drug called atezolizumab, which isWill those who responded to the vaccine remain cancer-free? Only longer follow-ups and larger trials will tell. If some cancer cells survived the combination treatment, they could evolve to resist the immune attack triggered by the vaccine. This is the reason why many tumours initially respond to treatments, but then evolve resistance. “You run the risk with every cancer type,” says Macdonald.That depends on the decisions of BioNTech and regulatory authorities, so it is impossible to say.
sipuleucel-T is a prostate cancer vaccine created by exposing immune cells to a prostate cancer-linked protein and then injecting those cells back into an individual’s body. There are also several vaccines that prevent cancer by limiting infections by the viruses that cause them, such as the HPV vaccines that areAn mRNA vaccine works by making our bodies produce a small quantity of specific proteins.
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