P53 could be key to therapies for salivary gland cancer umich
Mucoepidermoid carcinoma is a poorly understood salivary gland malignancy with limited therapeutic options. Cancer stem cells are considered drivers of cancer progression by mediating tumor recurrence and metastasis. We have shown that clinically relevant small molecule inhibitors of MDM2–p53 interaction activate p53 signaling and reduce the fraction of CSC in MEC.
Here we examined the functional role of p53 in the plasticity and self-renewal of MEC CSC.Using gene silencing and therapeutic activation of p53, we analyzed the cell-cycle profiles and apoptosis levels of CSCs in MEC cell lines via flow cytometry and looked at the effects on survival/self-renewal of the CSCs through sphere assays. We evaluated the effect of p53 on tumor development (
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