An ancient fish called a 'living fossil' has assisted scientists in gaining a deeper understanding of stem cells, which could potentially lead to advancements in stem cell research and the creation of artificial organs. A beating heart, a complex organ responsible for pumping blood throughout the
Illustration of the animals studied. Credit: Woranop Sukparangsi
However, this perception may change in the future as research progresses toward the creation of artificial organs, which have the potential to save the lives of those with organ failure. “The first step in stem cell research is to understand the gene regulatory network that supports so-called pluripotent stem cells. Understanding how their function was perfected in evolution can help provide knowledge about how to construct better stem cells,” says Joshua Mark Brickman.
In addition to the fact that the coelacanth is in a different class from mammals, it has also been called a ‘living fossil,’ since approximately 400 million years ago it developed into the form it has today. It has fins shaped like limbs and is therefore thought to resemble the first animals to move from the sea onto land.
And by studying the network in other species, such as this fish, the researchers can distill what the basic concepts that support a stem cell are.
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