The long-pursued goal of a permanent, one-dose contraceptive may have been achieved in female cats and it should work in other species too
are darted with a vaccine called PZP, which provokes an immune reaction in females that prevents pregnancies. However, repeated doses are required.
Swanson and his team have instead developed an approach that involves a single injection into the thigh muscle of cats. The injection contains DNA. The DNA is carried by a virus that delivers it to the nucleus of muscle cells, where it remains indefinitely. In a trial, six female cats received the contraceptive injection and three cats received a dummy injection. Each cat was housed with a male with proven fertility for two four-month periods. All of the untreated cats became pregnant, but none of those given the contraceptive did. “The cats are completely healthy. We are not seeing any adverse effects,” says Swanson.
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