Once called cellular debris, tiny bubbles may play key role in understanding, treating diseases
Scientists have long puzzled about a critical way that cells communicate with one another, but Rutgers researchers have used a simple roundworm to solve the mystery., could help to develop treatments for Alzheimer's and other neurodegenerative diseases.
"Although EVs are of profound medical importance, the field lacks a basic understanding of how EVs form, what cargo is packaged in different types of EVs originating from same or different cell types and how different cargos influence the range of EV targeting and bioactivities," said lead author Inna Nikonorova, a postdoctoral researcher.
Maureen Barr, a professor in the Department of Genetics, and Nikonorova developed a large-scale identification project that identified 2,888 EV cargo candidates. Nikonorova and Barr hypothesized that neurons package RNA-binding proteins and RNA into EVs to drive communication between cells and between animals. A fundamental understanding of EV-RNA biology is important for developing tailor-made EVs for RNA-based therapies.
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