Vaccines customized to fight individual viral strains aren't all that new. The question is, will they work for COVID?
Pei-Yong Shi, vaccine development expert
, an expert in vaccine development and virology at the University of Texas Medical Branch. “The companies have tried multiple modified sequences before,” he says. Moderna and Pfizer made shots for both the Beta and Delta variants that went through human trials. Data presented by Moderna showing the antibody response of its original Omicron bivalent booster against Omicron sublineages.Data presented by Moderna showing antibody responses in mice after vaccination with the updated BA.4/BA.5 bivalent booster.Data presented by Pfizer/BioNTech showing antibody responses against Omicron after vaccination with original Omicron bivalent booster.
the updated vaccine would simplify the confusing process for COVID boosters approval and eligibility. Going forward, it doesn’t matter how many shots a person has received in the past, or what risk group they’re in: Almost all boosters will be bivalent, and almost anyone who is two months out from their most recent vaccine will be eligible.
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